{"id":37864,"date":"2018-10-04T15:44:28","date_gmt":"2018-10-04T15:44:28","guid":{"rendered":"https:\/\/tiller.cronometerdev.com\/blog\/?p=37864"},"modified":"2025-02-10T13:08:28","modified_gmt":"2025-02-10T21:08:28","slug":"lowcarb-interview","status":"publish","type":"post","link":"https:\/\/cronometer.com\/blog\/lowcarb-interview\/","title":{"rendered":"The Year of Low Carb: Interview With Richard Feinman"},"content":{"rendered":"\t\t
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Interview with Dr. Richard Feinman, Professor of Cell Biology<\/strong><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Richard Feinman, PhD, is a cell biologist who is widely credited with doing some of the first serious scientific research on the Atkins Diet.  His career has spanned decades as low fat diets waxed and waned in public health recommendations. While he emphasizes not being an \u201dadvocate\u201d, he has continued to argue for the importance of  low carbohydrate diets as the first line of defense against diabetes, metabolic syndrome, and obesity.<\/p>\n

Read on to find out more about Richard Feinman and his findings.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Who Are You And What Do You Do?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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I\u2019m Richard Feinman, and I identify myself as Richard Feinman, The Other because I\u2019m often confused with the physicist and Nobel prize winner Richard Feynman.\u00a0 I\u2019ve been a Professor of Cell Biology at SUNY Downstate in Brooklyn, New York for many years.\u00a0 I\u2019m originally trained as an enzyme chemist and have worked in several fields, including behavioral neuroscience.\u00a0 My main research interest rests with the application of ketogenic diets for cancer. Currently I\u2019m also interested in the philosophy of science and how it applies to the accuracy and reliability of what is published in medical literature.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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How Did You Find An Interest In Low Carb Diets?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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I\u2019ve always known about low carb diets because I\u2019ve always been fighting fat.\u00a0 Judging from old photographs, I was never fat as a child, but I always had what they describe as a poor body image.\u00a0 I recognized by observation early on that the things that increased my weight were carbohydrates.\u00a0 Generally I knew what to eat, but like everyone with a weight problem I didn\u2019t always eat those things.<\/p>

Low carb diets became a professional issue for me when I began teaching metabolism to medical students.\u00a0 Metabolism is the science of how your food is transformed to provide energy to cellular material.\u00a0 The problem is that the interconversions of the substances derived from food (metabolites) is complicated.\u00a0 So the old idea that \u201cyou are what you eat\u201d is not really right because right after you\u2019ve eaten it it\u2019s immediately turned into something else.\u00a0 You are what your metabolism does to what you eat.\u00a0 Does your metabolism turn what you eat into fat, or does it burn it right away?<\/p>

In order to provide some kind of consistent theme to relate all the different parts of metabolism I use low carb diets as a model because low carb diets are the easiest way to illustrate how metabolism is controlled by a large number of different enzymes and hormones.\u00a0 Primary among them is insulin and the major source of insulin is carbohydrates, either dietary carbohydrates or carbohydrates from other substances in metabolism.\u00a0 Insulin is not the only important hormone, but I usually describe it as analogous to the role of the quarterback in American football.\u00a0 There are at least twenty two different things happening on the field at once, but you can understand things reasonably well by focusing on the quarterback.\u00a0 Insulin doesn\u2019t explain everything in metabolism, but like the quarterback, watching its role gives you a pretty good idea of what\u2019s going on.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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What Does Insulin Do?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Insulin is primarily an anabolic hormone, which means it builds things up.\u00a0 It will increase storage of fat and glycogen (where we store carbohydrate) and protein synthesis.\u00a0 Normally when you eat a meal, insulin goes up, the ingested fat is stored in the fat cells, and protein is used to make new cell material.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Why Is It Such A Major Player In Diabetes, Metabolic Syndrome And Obesity?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Metabolism has two goals: provide energy and keep glucose levels relatively constant. The first is not a major problem in that almost all of us have stored enough fat to live for weeks or even months in the absence of food. If you\u2019re on a starvation diet, your body stops storing fat and burns fat for energy, but what about regulating glucose?\u00a0<\/p>

The brain, central nervous system and red blood cells require glucose, and insulin regulates glucose.\u00a0 Unlike our fat stores, we maintain very limited accumulation of carbohydrate and to meet the second need, so you must make the glucose from something else.\u00a0 That\u2019s mostly protein.\u00a0\u00a0 Under those conditions, the body starts to consume its own protein for gluconeogenesis (new making of glucose). If you are without food or carbohydrate for very long, you have the danger of muscle wasting.\u00a0<\/p>

However, with a low carbohydrate diet, you have decreased insulin so decreased fat storage and increased burning of fat, but you also consume adequate protein so the body can create glucose without burning its own muscle tissue.<\/p>

That is why the Atkins diet and other low carbohydrate diets are so effective at helping people lose weight without losing muscle.\u00a0 The insulin lowering effect of the low carb diet also suggests it as the first line of treatment for metabolic syndrome and obesity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Can You Explain More About Low Carb Diets For Metabolic Syndrome And Diabetes?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr. Gerald Reaven, an endocrinologist who died just this past February, derived the concept of metabolic syndrome, which he first referred to as \u201cSyndrome X.\u201d\u00a0 Toward the end of his career her preferred the term \u201cinsulin resistance syndrome.\u201d\u00a0 He observed that central obesity (being \u201capple shaped\u201d), high blood pressure and diabetes all have two common causes: insulin resistance and impaired glucose tolerance.\u00a0\u00a0 Now we\u2019re used to the idea of metabolic syndrome, but at the time it was a radical insight.<\/p>

Diabetes is the classic insulin-controlled disease.\u00a0 In the 1920s, it was discovered that the defect in Type 1 diabetes was an inborn lack of insulin and you could treat Type 1 by administering insulin.\u00a0 Before that time it was treated with a low carb diet.\u00a0 When insulin was discovered you could now actually provide a cure for the Type 1 diabetes patient.\u00a0 The trouble is several fold.\u00a0 At that time the difference in Type 1 and 2 was misunderstood.\u00a0 Type 1 was seen as a hormone deficiency disease and you could replace the missing hormone with insulin and then you could eat carbs because all you had to do was pair the carbs with insulin.<\/p>

Diabetes is a hormone deficiency disease, but that\u2019s not the whole story.\u00a0 It\u2019s a systems disease.\u00a0 It\u2019s a breakdown in control due to the absence of insulin.\u00a0 By trying to regulate insulin externally, you get much greater fluctuations than you would have by regulating it with diet.\u00a0 For people with Type 1 diabetes, external insulin will always be necessary, but the systems disease can be improved with a low carb diet.\u00a0 There is no question that low carb diets should be the primary treatment for Type 2 diabetes.\u00a0 There are a large number of people who essentially are cured, and maintain insulin and blood sugar control as long as they remain on a low carb diet.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Why Has The Medical Establishment Been So Negative About Low Carb Diets?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Years ago, probably starting in the 1960\u2019s, the nutrition establishment became obsessed with fat and the idea that fat was the cause of heart disease.\u00a0 The idea might come from the fact that arteriosclerosis plaques have fat in them, but it\u2019s a big jump to say that fat is the key player in heart disease.<\/p>

This hypothesis was tested in the Framingham Study, which began in 1948 with just over 5,000 participants in the small town of Framingham, Massachusetts and is now on its third generation.\u00a0 The study participants recorded what they ate, what their activity level was, and other things.\u00a0 The goal was to tabulate all this information, look at rates of heart disease, and ask the question: what is the relationship between dietary factors and heart disease.\u00a0 But the experimenters weren\u2019t asking that question at all: what they were really asking is, \u201cCan I prove the Diet Heart Hypothesis?\u201d – the hypothesis that dietary fat causes heart disease.<\/p>

It turned out that there was no relationship between fat, saturated fat, cholesterol or heart disease.\u00a0 Early results showed that high fat diets increased cholesterol, but later results showed differently.\u00a0 For the past 30 years all of the tests of the Diet Heart hypothesis have been ambiguous at best.\u00a0 Where you find low fat diets providing benefit is also where the carbs are low – in overall low calorie diets.\u00a0 Most people feel that that a high saturated fat diet if it were also high carbohydrate might be a risk for heart disease (because glucose via insulin is catalytic and effects other nutrients) but it is hard to show even that.<\/p>

Resistance to low carbohydrate diets as a first line of treatment for diabetes, obesity and metabolic syndrome has come from the Diet Heart Hypothesis and the assumption that people would replace carbs with saturated fat.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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What's Changed And Why Do You Call 2018 The Year Of The Low Carb Diet<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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While the tests of the Diet Heart Hypothesis have consistently failed, studies on low carb diets for diabetes have consistently shown improvement.\u00a0 A real breakthrough paper came out this year by Dr. Sarah Hallberg and colleagues of Ohio University, working with Dr. Jeff Volek, a long term researcher in low carb diets and a powerlifter, both academically and personally.\u00a0 The paper, entitled, \u201cEffectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study<\/a>,\u201d showed that of over 300 patients with Type 2 diabetes who were put on a ketogenic diet along with continuous remote medication monitoring from a machine that provided feedback to care providers on patients,\u00a0 94%\u00a0 were able to eliminate or reduce the use of artificial insulin. Patients on the ketogenic diet also lowered their HbA1C (a measurement of blood sugar levels over time) from 7.6% to 6.3% and lowered their body weight by 12%.\u00a0 The 87 patients in the control group who received the usual care from their doctors and a diabetes education program experienced no changes in medication needs, weight or HbA1C.\u00a0 Meanwhile, no one in the ketogenic diet group had any adverse effects from the diet – there was no downside, only improvement.<\/p>

In late August, a meeting of researchers studying low carbohydrate diets for obesity, diabetes, neurological diseases such as epilepsy (for which ketogenic diets have long been one of the most effective treatments) and even cancer convened at Ohio State.\u00a0 There is much momentum for moving ahead with low carbohydrate diet research.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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What Happened Next?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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And then there was the wet blanket.\u00a0 Just as we were leaving the meeting, the\u00a0Lancet Public Health<\/em>\u00a0published an article<\/a>\u00a0saying that low carb diets would increase all-cause mortality.\u00a0 There were, however, no low carb diets. In fact, there were no diets at all in the sense of telling people what to eat, monitoring their response and evaluating pre-set hypotheses. The authors made up their own definition of a low-carb diet. They applied this to a previously published paper that was not intended to study low-carbohydrate diets (the name Arteriosclerosis Risk in Communities tells you what it was about).\u00a0 Patients were asked to estimate their food intake based on a food frequency questionnaire (FFQ), in itself is highly problematic methodology, as food recall is notoriously bad and biased, especially over long periods of time.\u00a0 Quick, what did you have for lunch last Monday?\u00a0 What about how frequently you ate any given group of food over the last few years? The data for each patient were responses to these FFQ\u2019s for two visits, six years apart. Some wit on the internet (maybe that was me) said it was a great project for a graduate student; you take a point every six years.\u00a0 It is obvious that this is not sophisticated research. You may well ask, \u201cHow could such a thing get into a major medical journal?\u201d I asked the editor and we\u2019ll see what she says.<\/p>

A final problem is that the definition researchers used as a low carbohydrate diet was 40% carb or less.\u00a0 That\u2019s not what most people in the field would call low carb.\u00a0 In fact, it is clear that although this paper was about low-carbohydrate diets, nobody with real experience of low-carbohydrate diets reviewed the paper or was consulted in any way.<\/p>

When you look at the actual results in the analysis, both those on what the researchers defined as \u201clow carb\u201d (40% or less) or high carb (70% or more) diets had a higher risk of all-cause mortality, but not by much.<\/p>

Finally, this study has redefined a \u201cmoderate\u201d carbohydrate consumption level as 50% – which is what we have now, in the midst of an epidemic of obesity and diabetes.<\/p>

Low carbohydrate diets have been proven to successfully treat diabetes, yet\u00a0The Lancet\u00a0<\/em>is telling people that they kill you.\u00a0 This is what turned me into a whistleblower: I\u2019m reacting not just as a scientist, but as a citizen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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What Do You Mean By Being A Whistleblower?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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I wrote an article critiquing this paper to\u00a0The Lancet<\/em>.\u00a0 They rejected it and said to write a letter to the editor.\u00a0 This isn\u2019t just bad science, it\u2019s a danger to real people.\u00a0 In this part, I\u2019m a citizen.\u00a0 I\u2019m not a health care provider but I do interact with many people with diabetes.\u00a0 What I see is parents with kids with Type 1 diabetes.\u00a0 The kids have to inject insulin and if they go on low carb they have much better control, need less insulin, and avoid the highs and lows that make life so difficult. And the parents avoid calls from school because the kid is in crisis and miserable.\u00a0 These guys who wrote\u00a0The Lancet\u00a0<\/em>study are telling parents not to do what helps kids.\u00a0 That\u2019s unconscionable.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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What's Next For You?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A new edition of my book:\u00a0The World Turned Upside Down: The Second Low-Carbohydrate Revolution<\/a><\/u>, is coming out soon.\u00a0 Meanwhile, I\u2019m working with groups of people with diabetes and others to spread the word to people who want to know what works.<\/p>

I told the publisher of my book that what I had to offer was the credentials of a practicing biochemist.\u00a0 I joked that I\u2019m almost the only biochemist dumb enough to stay in nutrition and she asked, \u201cWhy do you do it?\u201d\u00a0\u00a0 There are two reasons.\u00a0 First, the biochemistry is beautiful.\u00a0 It is still the power of science.\u00a0 Second, the Feinman family fault is righteous indignation: It\u2019s a terrible problem and we shouldn\u2019t let it persist.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Interview with Dr. Richard Feinman, Professor of Cell Biology Richard Feinman, PhD, is a cell biologist who is widely credited with doing some of the first serious scientific research on the Atkins Diet.  His career has spanned decades as low fat diets waxed and waned in public health recommendations. While he emphasizes not being an […]<\/p>\n","protected":false},"author":1,"featured_media":54798,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[7],"tags":[],"class_list":["post-37864","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nutrition"],"_links":{"self":[{"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/posts\/37864","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/comments?post=37864"}],"version-history":[{"count":0,"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/posts\/37864\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/media\/54798"}],"wp:attachment":[{"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/media?parent=37864"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/categories?post=37864"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cronometer.com\/blog\/wp-json\/wp\/v2\/tags?post=37864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}